Transdermal Therapeutic Systems (TTS)

What is TTS?

Transdermal Therapeutic Systems (TTS), or transdermal patches, deliver drugs to the body via skin absorption. TTS is a highly useful form of drug administration with many advantages. One advantage is immediate visual confirmation of administration when the patch is applied to the skin. Additionally, the formulas are designed to control the rate of drug absorption which helps to sustain drug-blood concentration over an extended period.

Advantages of TTS・Key Development Points
CDMO* Services for TTS
High Throughput Screening
Adhesives Used in TTS
Nitto’s Capabilities/Experiences

Advantages of TTS・Key Development Points

Advantages of TTS

Possible to control absorption speed by the formulation design
Easy to sustain drug blood concentration over an extended period
Avoids the first-pass metabolism by the liver
Easy to use (especially for patients with dysphagia)
Easy to check drug adherence
Stop drug administration by simply removing the patch

Key Development Points

Four Key Factors in TTS Development (Permeability, Safety, Stability, and Adhesion) and Nitto’s Approach

CDMO* Services for TTS

Our Services

Formulation Study
Process Development
Manufacturing (non-clinical, clinical, and commercial)
Free skin permeability examination of compounds by simulation.

Please feel free to contact us for more information.

*Contract Development and Manufacturing Organization

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High Throughput Screening

Nitto’s High Throughput Screening

We can evaluate the skin permeability of a large number of samples at once using our High Throughput Screening – an original method that uses only a small amount of Active Pharmaceutical Ingredients (API).

Adhesives Used in TTS

TTS requires the right adhesive technology to achieve its target properties, so Nitto uses its original acrylic adhesive technology to design the optimal formula.

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